Incidence of cirrhosis in Iceland—impact of the TraP HepC nationwide HCV elimination program ...
In 2016, a nationwide elimination program for hepatitis C virus (HCV) was initiated in Iceland, entitled Treatment as Prevention for Hepatitis C (TraP HepC), providing unrestricted access to antiviral treatment. The aims were to describe the changes in etiology and epidemiology of cirrhosis in Icela...
| Main Authors: | , , , , |
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| Format: | Text |
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Taylor & Francis
2024
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| Online Access: | https://dx.doi.org/10.6084/m9.figshare.25712690 https://tandf.figshare.com/articles/journal_contribution/Incidence_of_cirrhosis_in_Iceland_impact_of_the_TraP_HepC_nationwide_HCV_elimination_program/25712690 |
| Summary: | In 2016, a nationwide elimination program for hepatitis C virus (HCV) was initiated in Iceland, entitled Treatment as Prevention for Hepatitis C (TraP HepC), providing unrestricted access to antiviral treatment. The aims were to describe the changes in etiology and epidemiology of cirrhosis in Iceland and to assess the trends in HCV-related cirrhosis following TraP HepC. The study included all patients newly diagnosed with cirrhosis in 2016–2022. Diagnosis was based on liver elastography, histology, or 2 of 4 criteria: cirrhosis on imaging, ascites, varices, or elevated international normalized ratio (INR). Over the study period, 342 new cirrhosis patients were identified, 223 (65%) males, median age 62 years. The crude overall incidence was 13.8 cases per 100,000 inhabitants annually. The most common etiologies were alcohol-related liver disease (ALD) (40%), metabolic dysfunction-associated steatotic liver disease (MASLD) (28%), and HCV with or without alcohol overconsumption (15%). The number of HCV ... |
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