Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus Aspergillus candidus HDN15-152 ...

• Main Authors: Tang, Bingying, Zhang, Runfang, Zhang, Falei, Zhu, Tianjiao, Che, Qian, Li, Dehai, Zhang, Guojian
• Format: Text
• Language: unknown
• Published: Taylor & Francis 2024
• Subjects: Biochemistry; Microbiology; FOS Biological sciences; Environmental Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; Ecology; Biological Sciences not elsewhere classified; Cancer; Infectious Diseases; FOS Health sciences; Virology; Antarc*; Antarctic
• Online Access: https://dx.doi.org/10.6084/m9.figshare.25471561; https://tandf.figshare.com/articles/journal_contribution/Antiviral_and_cytotoxic_indole_diterpenoids_from_the_antarctic_sponge-derived_fungus_i_Aspergillus_candidus_i_HDN15-152/25471561

One new indole diterpenoid, ascandinine T ( 1 ), and three known analogues ( 2 – 4 ) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. All isolated compounds were tested for antiviral and anticancer activity. Compound 4 displayed antiviral activity against influenza A virus (IAV) of A/PR/8/34(H1N1) strain with an IC 50 value of 39.2 μ M, while compound 2 showed cytotoxicity against NCI-H446, NCI-H446/EP and L-02 cells with IC 50 values ranging from 9.77 to 13.91 μ M. ...