Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus Aspergillus candidus HDN15-152 ...

One new indole diterpenoid, ascandinine T ( 1 ), and three known analogues ( 2 – 4 ) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD...

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Bibliographic Details
Main Authors: Tang, Bingying, Zhang, Runfang, Zhang, Falei, Zhu, Tianjiao, Che, Qian, Li, Dehai, Zhang, Guojian
Format: Text
Language:unknown
Published: Taylor & Francis 2024
Subjects:
Biochemistry
Microbiology
FOS Biological sciences
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
FOS Health sciences
Virology
Antarc*
Antarctic
Online Access:https://dx.doi.org/10.6084/m9.figshare.25471561
https://tandf.figshare.com/articles/journal_contribution/Antiviral_and_cytotoxic_indole_diterpenoids_from_the_antarctic_sponge-derived_fungus_i_Aspergillus_candidus_i_HDN15-152/25471561
Description
Summary:One new indole diterpenoid, ascandinine T ( 1 ), and three known analogues ( 2 – 4 ) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. All isolated compounds were tested for antiviral and anticancer activity. Compound 4 displayed antiviral activity against influenza A virus (IAV) of A/PR/8/34(H1N1) strain with an IC 50 value of 39.2 μ M, while compound 2 showed cytotoxicity against NCI-H446, NCI-H446/EP and L-02 cells with IC 50 values ranging from 9.77 to 13.91 μ M. ...

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