Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus Aspergillus candidus HDN15-152 ...
One new indole diterpenoid, ascandinine T ( 1 ), and three known analogues ( 2 – 4 ) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD...
Main Authors: | , , , , , , |
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Format: | Text |
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Taylor & Francis
2024
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Online Access: | https://dx.doi.org/10.6084/m9.figshare.25471561 https://tandf.figshare.com/articles/journal_contribution/Antiviral_and_cytotoxic_indole_diterpenoids_from_the_antarctic_sponge-derived_fungus_i_Aspergillus_candidus_i_HDN15-152/25471561 |
Summary: | One new indole diterpenoid, ascandinine T ( 1 ), and three known analogues ( 2 – 4 ) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. All isolated compounds were tested for antiviral and anticancer activity. Compound 4 displayed antiviral activity against influenza A virus (IAV) of A/PR/8/34(H1N1) strain with an IC 50 value of 39.2 μ M, while compound 2 showed cytotoxicity against NCI-H446, NCI-H446/EP and L-02 cells with IC 50 values ranging from 9.77 to 13.91 μ M. ... |
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