Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 ...

• Main Authors: Yu, Hao-Bing, Hu, Bo, Kong, Jie, Li, Yun-Hai, He, Ying, Lu, Xiao-Ling, Jiao, Bing-Hua, Liu, Xiao-Yu
• Format: Text
• Language: unknown
• Published: Taylor & Francis 2021
• Subjects: Biochemistry; Microbiology; FOS Biological sciences; Pharmacology; Environmental Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; Ecology; Biological Sciences not elsewhere classified; Inorganic Chemistry; FOS Chemical sciences; Plant Biology; Antarctic; The Antarctic; Antarc*
• Online Access: https://dx.doi.org/10.6084/m9.figshare.14479144.v1; https://tandf.figshare.com/articles/journal_contribution/Palitantin_derivatives_from_the_Antarctic_fungus_i_Geomyces_i_sp_3-1/14479144/1

Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC 50 value of 7.9 μ M (ursolic acid as positive control, IC 50 = 8.3 μ M). ...