Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 ...

Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compou...

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Bibliographic Details
Main Authors: Yu, Hao-Bing, Hu, Bo, Kong, Jie, Li, Yun-Hai, He, Ying, Lu, Xiao-Ling, Jiao, Bing-Hua, Liu, Xiao-Yu
Format: Text
Language:unknown
Published: Taylor & Francis 2021
Subjects:
Biochemistry
Microbiology
FOS Biological sciences
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Biological Sciences not elsewhere classified
Inorganic Chemistry
FOS Chemical sciences
Plant Biology
Antarctic
The Antarctic
Antarc*
Online Access:https://dx.doi.org/10.6084/m9.figshare.14479144.v1
https://tandf.figshare.com/articles/journal_contribution/Palitantin_derivatives_from_the_Antarctic_fungus_i_Geomyces_i_sp_3-1/14479144/1
Description
Summary:Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC 50 value of 7.9 μ M (ursolic acid as positive control, IC 50 = 8.3 μ M). ...

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