Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 ...
Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compou...
Main Authors: | , , , , , , , |
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Format: | Text |
Language: | unknown |
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Taylor & Francis
2021
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Online Access: | https://dx.doi.org/10.6084/m9.figshare.14479144 https://tandf.figshare.com/articles/journal_contribution/Palitantin_derivatives_from_the_Antarctic_fungus_i_Geomyces_i_sp_3-1/14479144 |
Summary: | Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC 50 value of 7.9 μ M (ursolic acid as positive control, IC 50 = 8.3 μ M). ... |
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