Glyphosate and AMPA in human urine of HBM4EU-aligned studies: Part B adults ...
Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015-2020); Swiss HBM4EU study (2020); DIET-HBM Icela...
| Main Authors: | , , , , |
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| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
My University
2022
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| Subjects: | |
| Online Access: | https://dx.doi.org/10.60810/openumwelt-1866 https://openumwelt.de/handle/123456789/2627 |
| Summary: | Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015-2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019-2020); ESTEBAN France (2014-2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05-0.1 (micro)g/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 (mirco)g/L urine for Gly and between 0.21 and 0.38 (mirco)g/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no ... |
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