Lipase Catalysed Kinetic Resolution of Stiripentol ... : الدقة الحركية المحفزة لليباز من ستيريبينتول ...

Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24.This allowed isolation of (3S)-Stiripentol with an ee of 86 % and the corresponding (3R)-butanoate with an ee of 87 %.Enzymatic hydrolysis o...

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Bibliographic Details
Main Authors: Elisabeth Egholm Jacobsen, T. Anthonsen, Mohammed Farrag El‐Behairy, Eirik Sundby, Mohamed N. Aboul‐Enein, Mohamed I. Attia, Aida A. El‐Azzouny, Kamelia M. Amin, Mohamed Abdel‐Rehim
Format: Text
Language:English
Published: OpenAlex 2012
Subjects:
Enzyme Immobilization Techniques
Molecular Biology
Biochemistry, Genetics and Molecular Biology
Life Sciences
Biosynthesis and Engineering of Terpenoids
Metabolic Engineering and Synthetic Biology
Lipases
Chemistry
Kinetic resolution
Lipase
Candida antarctica
Hydrolysis
Resolution logic
Organic chemistry
Enzyme
Stereochemistry
Catalysis
Enantioselective synthesis
Artificial intelligence
Computer science
Antarc*
Antarctica
Online Access:https://dx.doi.org/10.60692/wkt1n-c5g75
https://gresis.osc.int//doi/10.60692/wkt1n-c5g75
Description
Summary:Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24.This allowed isolation of (3S)-Stiripentol with an ee of 86 % and the corresponding (3R)-butanoate with an ee of 87 %.Enzymatic hydrolysis of the ester product gave (3R)- ... : تم إجراء التحليل الحركي لـ rac - Stiripentol، المحفز بواسطة lipase A من المبيضات في القارة القطبية الجنوبية عن طريق الأسترة باستخدام بوتانوات الفينيل بقيمة E قدرها 24. وقد سمح هذا بعزل (3S) - Stiripentol مع ee بنسبة 86 ٪ و (3R) - butanoate المقابلة مع ee بنسبة 87 ٪. التحلل المائي الأنزيمي لمنتج الإستر المعطى (3R)- ...

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