Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus ...
(Uploaded by Plazi for the Bat Literature Project) Members of the family Hepadnaviridae fall into two subgroups: mammalian and avian. The detection of endogenous avian hepadnavirus DNA integrated into the genomes of zebra finches has revealed a deep evolutionary origin of hepadnaviruses that was not...
| Main Authors: | , , |
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| Format: | Article in Journal/Newspaper |
| Language: | unknown |
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Zenodo
2016
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| Subjects: | |
| Online Access: | https://dx.doi.org/10.5281/zenodo.13530863 https://zenodo.org/doi/10.5281/zenodo.13530863 |
| Summary: | (Uploaded by Plazi for the Bat Literature Project) Members of the family Hepadnaviridae fall into two subgroups: mammalian and avian. The detection of endogenous avian hepadnavirus DNA integrated into the genomes of zebra finches has revealed a deep evolutionary origin of hepadnaviruses that was not previously recognized, dating back at least 40 million and possibly >80 million years ago. The nonprimate mammalian members of the Hepadnaviridae include the woodchuck hepatitis virus (WHV), the ground squirrel hepatitis virus, and arctic squirrel hepatitis virus, as well as a number of members of the recently described bat hepatitis virus. The identification of hepatitis B viruses (HBVs) in higher primates, such as chimpanzee, gorilla, orangutan, and gibbons that cluster with the human HBV, as well as a number of recombinant forms between humans and primates, further implies a more complex origin of this virus. We discuss the current theories of the origin and evolution of HBV and propose a model that ... |
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