Histological assessment of cellular immune response to the phytohemagglutinin skin test in Brazilian free-tailed bats (Tadarida brasiliensis) ...

• Main Authors: Turmelle, Amy S., Ellison, James A., Mendonça, Mary T., McCracken, Gary F.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: Zenodo 2010
• Subjects: Bat; Bat immunology; Cellular immune response; Phytohemagglutinin; Biodiversity; Mammalia; Chiroptera; Chordata; Animalia; bats; bat; Antarc*; Antarctica
• Online Access: https://dx.doi.org/10.5281/zenodo.13528043; https://zenodo.org/doi/10.5281/zenodo.13528043

(Uploaded by Plazi for the Bat Literature Project) Bats are known reservoirs for numerous emerging infectious diseases, occupy unique ecological niches, and occur globally except for Antarctica. Given their impact on human and agricultural health, it is critical to understand the mechanisms underlying immunocompetence in this reservoir host. To date, few studies have examined immune function in the Order Chiroptera, particularly among natural colonies of bats. The phytohemagglutinin (PHA) skin test has been widely used to measure delayed-type cellular immune response in a wide variety of vertebrates, and has been routinely employed in immunoecological studies. Although this test is frequently described as a measure of T cell proliferation, recent studies indicate it may represent a combination of immune responses. In mammals, the immune response is differentially, temporally and spatially regulated, therefore, we characterized the infiltrating leukocyte response to the PHA skin test in bats by examining a ...