Data from: Evolutionary insights of interferon Lambda genes in Tetrapods ...
Type III interferon, also known as interferon lambda is an innate antiviral protein. We retrieved the IFN-λ and their receptors’ sequences belonging to forty-two tetrapod species and conducted computational evolutionary analysis to understand the gene’s diversity. The CNV of IFN-λ was determined thr...
| Main Authors: | , , , , , |
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| Format: | Dataset |
| Language: | English |
| Published: |
Dryad
2024
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| Subjects: | |
| Online Access: | https://dx.doi.org/10.5061/dryad.q2bvq83ts https://datadryad.org/stash/dataset/doi:10.5061/dryad.q2bvq83ts |
| Summary: | Type III interferon, also known as interferon lambda is an innate antiviral protein. We retrieved the IFN-λ and their receptors’ sequences belonging to forty-two tetrapod species and conducted computational evolutionary analysis to understand the gene’s diversity. The CNV of IFN-λ was determined through qPCR in Indian cattle and buffalo. The tetrapod species feature intron-containing type-III IFN genes. Some reptiles and placental mammal have two IFN-λ loci. While marsupials, monotremes, and birds have a single IFN-λ locus. Some of the placental mammals and amphibians exhibit multiple IFN-λ genes as intron-less and intron-containing. Placental mammals typically possess three to four functional IFN-λ genes, some of them lack signal peptides. IFN-λ of these tetrapod species formed three major clades. Mammalian IFN-λ4 appears as an ancestral form, with syntenic conservation in most mammalian species. The intron-less IFN-λ1 and both the type III IFN receptors have conserved synteny in tetrapod. Purifying ... : The Type III Interferon (interferon lambda) gene encoding Protein and nucleotide sequences of tetrapods were collected from the public databases like NCBI, UCSC genome browser, and Ensembl. The tetrapod species included in this study belonged to amphibians (African clawed frog, Tropical clawed frogs, and common toad), reptiles (Chinese alligator, green anole, American alligator, Chinese soft-shelled turtle, Pond turtle, and painted turtle), birds (Chicken and Pheasant), and mammals [monotreme (Platypus); marsupials (Opossum, common brush tail, and common wombat); and placental (human, rhesus monkey, gorilla, chimpanzee, mouse, rats, cats, tigers, hyaena, arctic fox, dogs, pigs, camels, horses, donkeys, African elephant, rhinoceros, Indian flying foxes, round leaf bats, mouse-eared bat, taurine cattle, buffalo, indigenous cattle, oryx, sheep, and goats]. Some of the sequences were annotated using FGENESH program. The evolutionary analysis of IFNL in tetrapods included phylogenetic analysis, synteny analysis, ... |
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