Data from: Gene duplication and divergence produce divergent MHC genotypes without disassortative mating ...
Genes of the major histocompatibility complex (MHC) exhibit heterozygote advantage in immune defence, which in turn can select for MHC-disassortative mate choice. However, many species lack this expected pattern of MHC-disassortative mating. A possible explanation lies in evolutionary processes foll...
| Main Authors: | , , , , , |
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| Format: | Dataset |
| Language: | English |
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Dryad
2016
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| Subjects: | |
| Online Access: | https://dx.doi.org/10.5061/dryad.j413n https://datadryad.org/stash/dataset/doi:10.5061/dryad.j413n |
| Summary: | Genes of the major histocompatibility complex (MHC) exhibit heterozygote advantage in immune defence, which in turn can select for MHC-disassortative mate choice. However, many species lack this expected pattern of MHC-disassortative mating. A possible explanation lies in evolutionary processes following gene duplication: if two duplicated MHC genes become functionally diverged from each other, offspring will inherit diverse multilocus genotypes even under random mating. We used locus-specific primers for high-throughput sequencing of two expressed MHC Class II B genes in Leach's storm-petrels, Oceanodroma leucorhoa, and found that exon 2 alleles fall into two gene-specific monophyletic clades. We tested for disassortative vs. random mating at these two functionally diverged Class II B genes, using multiple metrics and different subsets of exon 2 sequence data. With good statistical power, we consistently found random assortment of mates at MHC. Despite random mating, birds had MHC genotypes with ... : MHC allele sequences24 MHC Class II B alleles found at Ocle-DAB1 and Ocle-DAB2 in this sample of 188 adults and 22 nestlings. Each allele is trimmed to exon 2 and is described with a DNA sequence, an amino acid translation, and a GenBank accession number. Four alleles have an in-frame 3-bp deletion; this is indicated by '---' in the DNA sequence, but the gap is closed in the amino acid sequence.allele_sequences.txtWhat genetic data are available for each birdList of genetic data obtained for individuals in each of 94 nests. Columns are Year (year of nesting attempt: 2010 or 2013), Nest # (burrow number, unique within year but not between years), Adult Female Band # (leg band # of breeding female), Adult Male Band # (leg band # of breeding male), and then a series of Yes/No columns reporting whether genetic data are available for parents and for nestlings at MHC genes and at microsatellite loci.data_list_by_nest.csvMicrosatellite genotypesGenotypes of 188 adults and 34 nestlings at 15 microsatellite loci. ... |
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