Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds ...

• Main Authors: Forsberg, Simon K. G., Kierczak, Marcin, Ljungvall, Ingrid, Merveille, Anne-Christine, Gouni, Vassiliki, Wiberg, Maria, Willesen, Jakob Lundgren, Hanås, Sofia, Lequarré, Anne-Sophie, Sørensen, Louise Mejer, Tiret, Laurent, McEntee, Kathleen, Seppälä, Eija, Koch, Jørgen, Battaille, Géraldine, Lohi, Hannes, Fredholm, Merete, Chetboul, Valerie, Häggström, Jens, Carlborg, Örjan, Lindblad-Toh, Kerstin, Höglund, Katja
• Format: Dataset
• Language: English
• Published: Dryad 2016
• Subjects: breed specific sweep; Epistasis; Canis lupus familiaris; fructosamine; gene-gene interaction; diabetes; Belgian shepherd; breed; Canis lupus
• Online Access: https://dx.doi.org/10.5061/dryad.ft6fv; https://datadryad.org/stash/dataset/doi:10.5061/dryad.ft6fv

Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on CFA 3 (pcorrected ≈ 1.68 × 10−6) in Belgian shepherd dogs. The associated region and its close neighborhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed ... : Forsberg et al. Fructosamine dataForsberg_et_al_fructosamine_data.zip ...