Data from: Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture ...

Anterior cruciate ligament (ACL) rupture is common condition that can be devastating and life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL ruptures through rupture of the contralateral ACL or rupture of a graft repair is also common. Risk of rupture is incre...

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Bibliographic Details
Main Authors: Baker, Lauren A., Kirkpatrick, Brian, Rosa, Guilherme J.M., Gianola, Daniel, Valente, Bruno, Sumner, Julia P., Baltzer, Wendy, Hao, Zhengling, Binversie, Emily E., Volstad, Nicola, Piazza, Alexander, Sample, Susannah J., Muir, Peter, Rosa, Guilherme J. M.
Format: Dataset
Language:English
Published: Dryad 2018
Subjects:
Complex trait GWAS
Canis lupus familiaris
ACL
Canine GWAS
Canis lupus
Online Access:https://dx.doi.org/10.5061/dryad.8kk06
https://datadryad.org/stash/dataset/doi:10.5061/dryad.8kk06
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Summary:Anterior cruciate ligament (ACL) rupture is common condition that can be devastating and life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL ruptures through rupture of the contralateral ACL or rupture of a graft repair is also common. Risk of rupture is increased in females. ACL rupture is also common in dogs. Disease prevalence exceeds 5% in several dog breeds, ~100 fold higher than human beings. We provide insight into the genetic etiology of ACL rupture by genome-wide association study (GWAS) in a high-risk breed using 98 case and 139 control Labrador Retrievers. We identified 129 single nucleotide polymorphisms (SNPs) within 99 risk loci. Associated loci (P<5.0E-04) explained approximately half of phenotypic variance in the ACL rupture trait. Two of these loci were located in uncharacterized or non-coding regions of the genome. A chromosome 24 locus containing nine genes with diverse functions met genome-wide significance (P=3.63E-0.6). GWAS pathways were ... : cr237_dryad.famPlink binary format fam file for 237 Labrador retrievers phenotyped for ACL rupture. 1= unaffected, 2 = affectedcr237_dryad.bedPlink binary format .bed file for 237 labrador retrievers phenotyped for ACL rupturecr237_dryad.bimPlink binary format .bim file for 237 Labrador retrievers phenotyped for ACL rupture ...

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