Data from: Complex disease and phenotype mapping in the domestic dog ...

The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at...

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Bibliographic Details
Main Authors: Hayward, Jessica J., Castelhano, Marta G., Oliveira, Kyle C., Corey, Elizabeth, Balkman, Cheryl, Baxter, Tara L., Casal, Margret L., Center, Sharon A., Fang, Meiying, Garrison, Susan J., Kalla, Sara E., Korniliev, Pavel, Kotlikoff, Michael I., Moise, N. Sydney, Shannon, Laura M., Simpson, Kenneth W., Sutter, Nathan B., Todhunter, Rory J., Boyko, Adam R.
Format: Dataset
Language:English
Published: Dryad 2016
Subjects:
Canis lupus familiaris
domestic dog
Genome-wide association study
complex disease
Canis lupus
Online Access:https://dx.doi.org/10.5061/dryad.266k4
https://datadryad.org/stash/dataset/doi:10.5061/dryad.266k4
Description
Summary:The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at 180,000 markers, to accelerate mapping efforts. For complex diseases, we identify loci significantly associated with hip dysplasia, elbow dysplasia, idiopathic epilepsy, lymphoma, mast cell tumour and granulomatous colitis; for morphological traits, we report three novel quantitative trait loci that influence body size and one that influences fur length and shedding. Using simulation studies, we show that modestly larger sample sizes and denser marker sets will be sufficient to identify most moderate- to large-effect complex disease loci. This proposed design will enable efficient mapping of canine complex diseases, most of which have human homologues, using far fewer samples than required in human studies. ... : plink files for cornell canine datasetID and sex information for each dogcornell_canine.famplink files for cornell canine datasetchromosome, name, location, alleles for each SNPcornell_canine.bimplink files for cornell canine datasetgenotypes for each dog at each SNPcornell_canine.bedphenotypesphenotypes for each dog ...

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