Evolutionary trajectory of the enzyme activation-induced cytidine deaminase (AID) within the Gadiformes lineage ...
Activation-induced cytidine deaminase (AID) is a DNA-mutating enzyme that initiates secondary antibody diversification process upon immune stimulation. One outcome of this diversification is the generation of antibodies with higher affinity for the cognate antigen. In human and mouse models, functio...
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| Format: | Text |
| Language: | English |
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Memorial University of Newfoundland
2021
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| Online Access: | https://dx.doi.org/10.48336/ntw6-y520 https://research.library.mun.ca/15749/ |
| Summary: | Activation-induced cytidine deaminase (AID) is a DNA-mutating enzyme that initiates secondary antibody diversification process upon immune stimulation. One outcome of this diversification is the generation of antibodies with higher affinity for the cognate antigen. In human and mouse models, functional deficiency of AID leads to hyper IgM syndrome type Ⅱ, exhibiting lack of secondary antibody diversification. Despite the central role of AID in instigating this diversification process, its off-targeting activity has been attributed to the initiation and progression of various type of cancers. The emergence of AID and, therefore, secondary antibody diversification process have been dated back to the common ancestor of jawed vertebrates. However, several studies investigating the Atlantic cod (Gadus morhua) immune responses revealed lack of high affinity antibodies and robust humoral response in this species. Moreover, genomic sequence of several Gadiformes species, including Atlantic cod, uncovered the loss of ... |
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