Identification of factors associated with non-responders to total joint replacement and sustained knee pain in primary osteoarthritis patients by epidemiological and multi-omic studies ...
Osteoarthritis (OA) is among the most common rheumatic diseases, affecting 30% of the world’s population over 60 years. Currently, total joint replacement (TJR) is considered the most effective treatment for end-stage OA. However, up to 20% of patients do not see clinically significant improvement i...
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| Format: | Text |
| Language: | English |
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Memorial University of Newfoundland
2023
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| Online Access: | https://dx.doi.org/10.48336/h8ab-7h31 https://research.library.mun.ca/16185/ |
| Summary: | Osteoarthritis (OA) is among the most common rheumatic diseases, affecting 30% of the world’s population over 60 years. Currently, total joint replacement (TJR) is considered the most effective treatment for end-stage OA. However, up to 20% of patients do not see clinically significant improvement in pain or function after the surgery. This thesis aims to identify epidemiological, metabolic, and genetic factors which are significantly associated with non-responders to TJR and patients with sustained, treatment-resistant pain in a large cohort from Newfoundland and Labrador (NL), Canada. First, we identified a number of epidemiological factors significantly associated with non-responders to TJR including clinical depression, younger age, and multisite musculoskeletal pain (MSMP). This highlighted potential roles for altered pain perception and pain sensitization in non-responders. Subsequently, we used a targeted metabolomic approach which profiled 186 metabolites in plasma and identified three metabolite ... |
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