Effects of ACTH-Induced Long-Term Hypercortisolism on the Transcriptome of Canine Visceral Adipose Tissue ...

Cushing's syndrome, or hypercortisolism (HC), a common endocrinopathy in adult dogs, is caused by chronic hypercortisolemia. Among different metabolic disorders, this syndrome is associated with enhanced subcutaneous lipolysis and visceral adiposity. However, effects of HC in adipose tissue, es...

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Bibliographic Details
Main Authors: Pereira, Miguel Tavares, Martin, Isabelle, Rehrauer, Hubert, Kowalewski, Mariusz P., Boretti, Felicitas S., Sieber-Ruckstuhl, Nadja S.
Format: Article in Journal/Newspaper
Language:English
Published: ETH Zurich 2022
Subjects:
dog Canis lupus familiaris
Cushing's syndrome
atherosclerosis
animal model
Canis lupus
Online Access:https://dx.doi.org/10.3929/ethz-b-000555940
http://hdl.handle.net/20.500.11850/555940
Description
Summary:Cushing's syndrome, or hypercortisolism (HC), a common endocrinopathy in adult dogs, is caused by chronic hypercortisolemia. Among different metabolic disorders, this syndrome is associated with enhanced subcutaneous lipolysis and visceral adiposity. However, effects of HC in adipose tissue, especially regarding visceral adipose tissue (VAT), are still poorly understood. Herein, the transcriptomic effects of chronic HC on VAT of dogs were evaluated. For this, subcutaneously implanted ACTH-releasing pumps were used, followed by deep RNA sequencing of the canine VAT. Prolonged HC seems to affect a plethora of regulatory mechanisms in VAT of treated dogs, with 1190 differentially expressed genes (DEGs, p and FDR < 0.01) being found. The 691 downregulated DEGs were mostly associated with functional terms like cell adhesion and migration, intracellular signaling, immune response, extracellular matrix and angiogenesis. Treatment also appeared to modulate local glucocorticoid and insulin signaling and hormonal ... : Veterinary Sciences, 9 (6) ...

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