CORRECTING INFLUENCE OF DIHYDROQUERCETIN ON THE STATE OF OXIDIZING METABOLISM AT PERSONS RESIDENT IN THE CITIES OF KHANTY-MANSIYSK AUTONOMOUS OKRUG WITH LOW QUALITY OF PLUMBING WATER TREATMENT
The natural waters of the KhantyMansiysk Autonomous Okrug (KMAO, Tyumen Oblast) are distinguished by an increased content of Fe and Mn (2.6 and 1.7 times higher than the maximum permissible concentration, respectively). In 71 residents of KMAO cities (Nyagan, Nefteyugansk) with poorquality water tre...
| Main Authors: | , , |
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| Format: | Conference Object |
| Language: | English |
| Published: |
Инфинити
2019
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| Subjects: | |
| Online Access: | https://dx.doi.org/10.34660/inf.2019.16.36669 http://naukarus.ru/public_html/wp-content/uploads/2019/Scientific research of the SCO countries - English Reports - September 14 - Part 1.pdf#page=130 |
| Summary: | The natural waters of the KhantyMansiysk Autonomous Okrug (KMAO, Tyumen Oblast) are distinguished by an increased content of Fe and Mn (2.6 and 1.7 times higher than the maximum permissible concentration, respectively). In 71 residents of KMAO cities (Nyagan, Nefteyugansk) with poorquality water treatment (artesian water is disinfected with chlorine), lipid peroxidation (LPO) indicators were previously determined: lipid hydroperoxides HPL and thiabarbituric acid active products TBAAP, which turned out to exceed the upper limit of physiological values. Indicators of the antioxidant defense system (ADS): total antioxidant activity TAA and thiol status TS were below the lower boundary of the reference values. It was found that the coefficient of oxidative stress (COS) exceeded by more than 6.7 times the upper limit of the maximum allowable level. For the purpose of metabolic correction, all examined individuals took an antioxidant drug of plant origin dihydroquercetin (DHQ) at a dose of 60 mg / day for 30 days. After correction, a statistically significant (p 0.001) decrease of 1.3 times in LPO products and a 2.3fold increase (p 0.001) of OAA, an increase in TS of almost 1.2 times against the background of a significant decrease in COS of more than 4.7 times (p 0.001). Thus, the intake of the natural antioxidant dihydroquercetin for a month at a dose of 60 mg / day contributed to a decrease in the content of LPO products, a decrease in COS, and an increase in the ADS activity of the bodys defense in residents of KMAO cities with poorquality water treatment. |
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