Controversies in omega-3 efficacy and novel concepts for application ...

Interest in the cardioprotective effects of long chain omega-3 polyunsaturated fatty acids (LCn3) was largely influenced by the low rates of cardiovascular disease (CVD) amongst the Inuits of Greenland who consumed a high marine fat diet rich in LCn3s. This finding stimulated years of epidemiologica...

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Bibliographic Details
Main Authors: Radcliffe, J. E., Thomas, Julian, Bramley, A. L., Kouris-Blazos, A., Radford, B. E., Scholey, Andrew, Pipingas, Andrew, Thomas, C. J., Itsiopoulos, C.
Format: Text
Language:unknown
Published: Swinburne 2024
Subjects:
Behavioural genetics
Behavioural neuroscience
Cognitive neuroscience
Psychopharmacology
Psychophysiology
Social and affective neuroscience
Clinical neuropsychology
Cognition
Learning, motivation and emotion
Greenland
inuits
Online Access:https://dx.doi.org/10.25916/sut.26221331.v1
https://swinburne.figshare.com/articles/journal_contribution/Controversies_in_omega-3_efficacy_and_novel_concepts_for_application/26221331/1
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Summary:Interest in the cardioprotective effects of long chain omega-3 polyunsaturated fatty acids (LCn3) was largely influenced by the low rates of cardiovascular disease (CVD) amongst the Inuits of Greenland who consumed a high marine fat diet rich in LCn3s. This finding stimulated years of epidemiological and clinical studies investigating the cardioprotective effects of LCn3s, thought to be primarily mediated through anti-inflammatory (and anti-aggregatory) prostaglandins that protect the vascular wall from pro-inflammatory effects of metabolic stress precipitated by poor diet and lifestyle. Although the original hypothesis of the link between LCn3s and CVD protection was based on a high LCn3 containing diet (namely a high marine fat diet) the majority of clinical trials since have focussed on EPA and DHA supplementation, and results of repeated meta-analyses have not shown conclusive evidence in support of their beneficial health effects. In this review we focus on the controversies that surround the efficacy ...

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