Анализ клинических исходов у пациентов с гастродуоденальными заболеваниями в зависимости от вариантов гена vacA Helicobacter pylori в Якутии : Analysis of clinical outcomes in patients with gastroduodenal diseases depending on vacA Helicobacter pylori gene variants in Yakutia

• Published in: Yakut Medical Journal
• Main Authors: Готовцев, Ньургун Наумович, Барашков, Николай Алексеевич, Борисова, Туяра Валерьевна, Пак, Мария Владимировна, Алексеева, Мавра Павловна, Лоскутова, Кюнняй Саввична, Пшенникова, Вера Геннадиевна, Леханова, Саргылана Николаевна, Федорова, Сардана Аркадьевна
• Format: Text
• Language: Russian
• Published: ФГБНУ "Якутский научный центр комплексных медицинских проблем" 2020
• Subjects: Helicobacter pylori; гастродуоденальные заболевания; ген vacA; Якутия; Yakutia; Yakuts; Якути*
• Online Access: https://dx.doi.org/10.25789/ymj.2020.72.18; http://ymj.mednauka.com/data/72/72-18.pdf

В статье приводятся результаты изучения клинических исходов у пациентов с гастродуоденальными заболеваниями в зависимости от вариантов гена vacA Helicobacter pylori в Якутии. Не выявлено ассоциаций в зависимости от пола пациентов, их места рождения или проживания. Однако статистически значимые отличия в распределении аллелей гена vacA были найдены в зависимости от пациентов с хроническим гастритом сопровождаемые эрозиями и язвами. Полученные результаты согласуются с результатами работ других исследователей. : A vacA gene is important virulence factor that encodes vacuolating toxin and presents in all strains of Helicobacter pylori. There is significant difference between strains in vacuolating activity determined by different sequences in the middle (m) and signal (s) regions. Helicobacter pylori vacAm has ml and m2 alleles, vacAs has si and s2 alleles. The higher grade of cytotoxic activity shows Helicobacter pylori with vacAslml strains than s1m2, while s2m2 has not produced vacuolating cytotoxin. The effect of vacA gene alleles on gastroduodenal diseases in patients of Yakutia earlier has not been studied. The aim of this work is an associative analysis of the clinical outcomes of the vacA Helicobacter pylori variant gene and its association with the course of gastroduodenal diseases among Yakuts. According to the results of the histological report, 154 patients (out of 322 examined) were included in the study, who had H. pylori in the antrum of the stomach. Patients were divided into two groups: chronic gastritis (n=65) and chronic gastritis with erosive and ulcerative lesions (n=89). The average age was --26,6 years. The diagnosis of chronic gastritis was established in 65 cases (42,2%), and chronic gastritis with erosive and ulcerative lesions was diagnosed in 89 cases (57,7%). A vacAslml was found in 30 out of 39 patients with erosive and ulcerative lesions (76,9%) (p<0,05) and 9 out of 39 patients - in the sample with chronic gastritis (23,1%) (p<0,05). Other patients (n=115) did not have statistically significant differences in comparable groups. High percentage of vacAslml alleles in patients with erosive gastritis in Yakutia suggests the hypothesis that this strain is the most cytotoxic and more common for severe forms of gastritis in peptic ulcer disease. : Якутский медицинский журнал, Выпуск 4 (72) 2020, Pages 69-73