Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice

Transgenic mice carrying the Arctic (E693G) and Swedish (KM670/6701NL) amyloid-b precursor protein (AβPP) develop amyloid-beta (Aβ) deposits in the brain that resemble Alzheimer’s disease neuropathology. The tg-ArcSwe atlas provides access to Aβx-40 immunolabeled histological section images from rep...

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Bibliographic Details
Main Authors: Lillehaug, S., Syverstad, G., Nilsson, L., Bjaalie, J.G., Leergaard, T.B., Torp, R.
Format: Dataset
Language:unknown
Published: Human Brain Project Neuroinformatics Platform 2018
Subjects:
Neuroscience
Arctic
Lillehaug
Online Access:https://dx.doi.org/10.25493/g6cq-d4d
https://kg.ebrains.eu/instances/Dataset/7e972a9c1c1fc2bb493d09512f6550d5
Description
Summary:Transgenic mice carrying the Arctic (E693G) and Swedish (KM670/6701NL) amyloid-b precursor protein (AβPP) develop amyloid-beta (Aβ) deposits in the brain that resemble Alzheimer’s disease neuropathology. The tg-ArcSwe atlas provides access to Aβx-40 immunolabeled histological section images from representative 12 month old tg-ArcSwe mice (Lord et al., Neurobiol. Aging 27:67-77, 2006), showing the morphology and spatial distribution of Aβx-40 plaque deposits across the brain. Analyses show that plaques are primarily distributed in the cerebral cortex, hippocampus, and thalamus. The average Aβ burden in the cortex and hippocampus is similar across animals, with coefficients of variance of 22% and 25%, respectively (Lillehaug et al., Neurobiol Aging 35:556-564, 2014).

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