All-cause and cause-specific mortality by spirometric pattern and sex – a population-based cohort study ...

• Main Authors: Backman, Helena, Sawalha, Sami, Nilsson, Ulf, Hedman, Linnea, Stridsman, Caroline, Vanfleteren, Lowie E. G. W., Nwaru, Bright I., Stenfors, Nikolai, Rönmark, Eva, Lindberg, Anne
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: SAGE Journals 2024
• Subjects: Aged Health Care; Pharmacology and Pharmaceutical Sciences not elsewhere classified; Respiratory Diseases; Northern Sweden
• Online Access: https://dx.doi.org/10.25384/sage.c.7115882.v1; https://sage.figshare.com/collections/All-cause_and_cause-specific_mortality_by_spirometric_pattern_and_sex_a_population-based_cohort_study/7115882/1

Background:Chronic airway obstruction (CAO) and restrictive spirometry pattern (RSP) are associated with mortality, but sex-specific patterns of all-cause and specific causes of death have hardly been evaluated.Objectives:To study the possible sex-dependent differences of all-cause mortality and patterns of cause-specific mortality among men and women with CAO and RSP, respectively, to that of normal lung function (NLF).Design:Population-based prospective cohort study.Methods:Individuals with CAO [FEV 1 /vital capacity (VC) < 0.70], RSP [FEV 1 /VC ⩾ 0.70 and forced vital capacity (FVC) < 80% predicted] and NLF (FEV 1 /VC ⩾ 0.70 and FVC ⩾ 80% predicted) were identified within the Obstructive Lung Disease in Northern Sweden (OLIN) studies in 2002–2004. Mortality data were collected through April 2016, totally covering 19,000 patient-years. Cox regression and Fine–Gray regression accounting for competing risks were utilized to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for ...