Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study. ...

OBJECTIVE: Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study...

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Bibliographic Details
Main Authors: Metcalf, Stephen A, Jones, Peter B, Nordstrom, Tanja, Timonen, Markku, Mäki, Pirjo, Miettunen, Jouko, Jääskeläinen, Erika, Järvelin, Marjo-Riitta, Stochl, Jan, Murray, Graham K, Veijola, Juha, Khandaker, Golam M
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier BV 2017
Subjects:
Adolescent
Adult
C-reactive protein
Inflammatory markers
Longitudinal study
Psychotic disorders
Schizophrenia
Systemic inflammation
Age of Onset
C-Reactive Protein
Cohort Studies
Cross-Sectional Studies
Female
Finland
Humans
International Classification of Diseases
Longitudinal Studies
Male
Prospective Studies
Psychiatric Status Rating Scales
Psychotic Disorders
Registries
Risk
Young Adult
Northern Finland
Online Access:https://dx.doi.org/10.17863/cam.6180
https://www.repository.cam.ac.uk/handle/1810/261012
Description
Summary:OBJECTIVE: Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study of serum C-reactive protein (CRP) in adolescence and subsequent risk of schizophrenia and related psychoses in adulthood in the Northern Finland Birth Cohort 1986. METHOD: Serum high-sensitivity CRP was measured at age 15/16 years in 6362 participants. ICD-10 diagnoses of schizophrenia and related psychoses were obtained from centralised hospital inpatient and outpatient registers up to age 27 years. Logistic regression calculated odds ratios (ORs) for psychotic outcomes associated with baseline CRP levels analysed as both continuous and categorical variables using American Heart Association criteria. Age, sex, body mass index, maternal education, smoking, and alcohol use were included as potential confounders. ...

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