Adolescent inhalant use and psychosis risk - a prospective longitudinal study. ...

BACKGROUND: Cross-sectional studies have suggested inhalant use is associated with psychosis. This association was examined in a longitudinal study accounting for other substance use and potential confounders. METHODS: We used a prospective sample (N = 6542) from the Northern Finland Birth Cohort 19...

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Bibliographic Details
Main Authors: Mustonen, Antti, Niemelä, Solja, McGrath, John J, Murray, Graham K, Nordström, Tanja, Mäki, Pirjo, Miettunen, Jouko, Scott, James G
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier BV 2018
Subjects:
Birth cohort
Psychotic disorders
Schizophrenia
Substance abuse
Adolescent
Adolescent Behavior
Adult
Bipolar Disorder
Comorbidity
Depressive Disorder, Major
Family
Follow-Up Studies
Humans
Incidence
Inhalant Abuse
Longitudinal Studies
Mental Disorders
Prospective Studies
Psychotic Disorders
Risk Factors
Northern Finland
Online Access:https://dx.doi.org/10.17863/cam.33134
https://www.repository.cam.ac.uk/handle/1810/285790
Description
Summary:BACKGROUND: Cross-sectional studies have suggested inhalant use is associated with psychosis. This association was examined in a longitudinal study accounting for other substance use and potential confounders. METHODS: We used a prospective sample (N = 6542) from the Northern Finland Birth Cohort 1986. Self-report questionnaires on substance use and psychotic experiences were completed when the cohort members were 15-16 years old. Inhalant use was categorized into four groups (never, once, 2-4 times, 5 times or more). Subsequent psychosis diagnoses (ICD-10) until age 30 years were obtained from national registers. Cox regression analysis was used to examine the association between adolescent inhalant use and risk of psychosis. RESULTS: During the observation period 124 individuals were diagnosed with incident psychosis. Overall, there were 225 (3.4%) subjects with any inhalant use, 18 (8.0%) of whom were diagnosed with psychosis during the follow up. Of non-inhalant users (n = 6317) 106 (1.7%) were diagnosed ...

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