Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ...
Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer t...
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ftdatacite:10.17863/cam.26964 2024-02-27T08:41:11+00:00 Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ... Mühlemann, Barbara Margaryan, Ashot Damgaard, Peter De Barros Allentoft, Morten E Vinner, Lasse Hansen, Anders J Weber, Andrzej Bazaliiskii, Vladimir I Molak, Martyna Arneborg, Jette Bogdanowicz, Wieslaw Falys, Ceri Sablin, Mikhail Smrčka, Václav Sten, Sabine Tashbaeva, Kadicha Lynnerup, Niels Sikora, Martin Smith, Derek J Fouchier, Ron AM Drosten, Christian Sjögren, Karl-Göran Kristiansen, Kristian Willerslev, Eske Jones, Terry C 2018 https://dx.doi.org/10.17863/cam.26964 https://www.repository.cam.ac.uk/handle/1810/279593 en eng Proceedings of the National Academy of Sciences ancient DNA paleo virology parvovirus B19 virology virus evolution Erythema Infectiosum Evolution, Molecular Genome, Viral Genotype History, 19th Century History, 20th Century Humans Parvovirus B19, Human Phylogeny Sequence Analysis, DNA article-journal ScholarlyArticle JournalArticle Article 2018 ftdatacite https://doi.org/10.17863/cam.26964 2024-02-01T14:55:05Z Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to ∼70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from ∼0.5 to ∼6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is ... Article in Journal/Newspaper Greenland DataCite Metadata Store (German National Library of Science and Technology) Greenland Kya ENVELOPE(8.308,8.308,63.772,63.772) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
ancient DNA paleo virology parvovirus B19 virology virus evolution Erythema Infectiosum Evolution, Molecular Genome, Viral Genotype History, 19th Century History, 20th Century Humans Parvovirus B19, Human Phylogeny Sequence Analysis, DNA |
spellingShingle |
ancient DNA paleo virology parvovirus B19 virology virus evolution Erythema Infectiosum Evolution, Molecular Genome, Viral Genotype History, 19th Century History, 20th Century Humans Parvovirus B19, Human Phylogeny Sequence Analysis, DNA Mühlemann, Barbara Margaryan, Ashot Damgaard, Peter De Barros Allentoft, Morten E Vinner, Lasse Hansen, Anders J Weber, Andrzej Bazaliiskii, Vladimir I Molak, Martyna Arneborg, Jette Bogdanowicz, Wieslaw Falys, Ceri Sablin, Mikhail Smrčka, Václav Sten, Sabine Tashbaeva, Kadicha Lynnerup, Niels Sikora, Martin Smith, Derek J Fouchier, Ron AM Drosten, Christian Sjögren, Karl-Göran Kristiansen, Kristian Willerslev, Eske Jones, Terry C Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ... |
topic_facet |
ancient DNA paleo virology parvovirus B19 virology virus evolution Erythema Infectiosum Evolution, Molecular Genome, Viral Genotype History, 19th Century History, 20th Century Humans Parvovirus B19, Human Phylogeny Sequence Analysis, DNA |
description |
Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to ∼70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from ∼0.5 to ∼6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is ... |
format |
Article in Journal/Newspaper |
author |
Mühlemann, Barbara Margaryan, Ashot Damgaard, Peter De Barros Allentoft, Morten E Vinner, Lasse Hansen, Anders J Weber, Andrzej Bazaliiskii, Vladimir I Molak, Martyna Arneborg, Jette Bogdanowicz, Wieslaw Falys, Ceri Sablin, Mikhail Smrčka, Václav Sten, Sabine Tashbaeva, Kadicha Lynnerup, Niels Sikora, Martin Smith, Derek J Fouchier, Ron AM Drosten, Christian Sjögren, Karl-Göran Kristiansen, Kristian Willerslev, Eske Jones, Terry C |
author_facet |
Mühlemann, Barbara Margaryan, Ashot Damgaard, Peter De Barros Allentoft, Morten E Vinner, Lasse Hansen, Anders J Weber, Andrzej Bazaliiskii, Vladimir I Molak, Martyna Arneborg, Jette Bogdanowicz, Wieslaw Falys, Ceri Sablin, Mikhail Smrčka, Václav Sten, Sabine Tashbaeva, Kadicha Lynnerup, Niels Sikora, Martin Smith, Derek J Fouchier, Ron AM Drosten, Christian Sjögren, Karl-Göran Kristiansen, Kristian Willerslev, Eske Jones, Terry C |
author_sort |
Mühlemann, Barbara |
title |
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ... |
title_short |
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ... |
title_full |
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ... |
title_fullStr |
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ... |
title_full_unstemmed |
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ... |
title_sort |
ancient human parvovirus b19 in eurasia reveals its long-term association with humans. ... |
publisher |
Proceedings of the National Academy of Sciences |
publishDate |
2018 |
url |
https://dx.doi.org/10.17863/cam.26964 https://www.repository.cam.ac.uk/handle/1810/279593 |
long_lat |
ENVELOPE(8.308,8.308,63.772,63.772) |
geographic |
Greenland Kya |
geographic_facet |
Greenland Kya |
genre |
Greenland |
genre_facet |
Greenland |
op_doi |
https://doi.org/10.17863/cam.26964 |
_version_ |
1792048447488000000 |