Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. ...

Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer t...

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Bibliographic Details
Main Authors: Mühlemann, Barbara, Margaryan, Ashot, Damgaard, Peter De Barros, Allentoft, Morten E, Vinner, Lasse, Hansen, Anders J, Weber, Andrzej, Bazaliiskii, Vladimir I, Molak, Martyna, Arneborg, Jette, Bogdanowicz, Wieslaw, Falys, Ceri, Sablin, Mikhail, Smrčka, Václav, Sten, Sabine, Tashbaeva, Kadicha, Lynnerup, Niels, Sikora, Martin, Smith, Derek J, Fouchier, Ron AM, Drosten, Christian, Sjögren, Karl-Göran, Kristiansen, Kristian, Willerslev, Eske, Jones, Terry C
Format: Article in Journal/Newspaper
Language:English
Published: Proceedings of the National Academy of Sciences 2018
Subjects:
ancient DNA
paleo virology
parvovirus B19
virology
virus evolution
Erythema Infectiosum
Evolution, Molecular
Genome, Viral
Genotype
History, 19th Century
History, 20th Century
Humans
Parvovirus B19, Human
Phylogeny
Sequence Analysis, DNA
Greenland
Kya
Online Access:https://dx.doi.org/10.17863/cam.26964
https://www.repository.cam.ac.uk/handle/1810/279593
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Summary:Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to ∼70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from ∼0.5 to ∼6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is ...

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