Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis. ...

BACKGROUND: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial. Aims To examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other...

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Bibliographic Details
Main Authors: Mustonen, Antti, Niemelä, Solja, Nordström, Tanja, Murray, Graham K, Mäki, Pirjo, Jääskeläinen, Erika, Miettunen, Jouko
Format: Article in Journal/Newspaper
Language:English
Published: Royal College of Psychiatrists 2018
Subjects:
Adolescent
Adolescent Behavior
Adult
Female
Finland
Follow-Up Studies
Humans
Male
Marijuana Use
Prodromal Symptoms
Psychotic Disorders
Registries
Risk
Young Adult
Northern Finland
Online Access:https://dx.doi.org/10.17863/cam.22972
https://www.repository.cam.ac.uk/handle/1810/275709
Description
Summary:BACKGROUND: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial. Aims To examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders. METHOD: The sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15-16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers. RESULTS: The risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0-13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1-8.0). CONCLUSIONS: Adolescent cannabis use ...

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