Lipase B from Candida antartica : applications to industrial polyester synthesis. ...
In the early 1990s, enzymatic polymerization studies on an unactivated adipic acid (A) / butane-1,4-diol (B) system in anhydrous organic media suggested that in solvent-free conditions a step-growth mechanism operates involving the effective sequential addition of an 'AB' unit. Subsequent...
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| Format: | Thesis |
| Language: | unknown |
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University of Liverpool Repository
2023
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| Online Access: | https://dx.doi.org/10.17638/03175458 https://livrepository.liverpool.ac.uk/id/eprint/3175458 |
| Summary: | In the early 1990s, enzymatic polymerization studies on an unactivated adipic acid (A) / butane-1,4-diol (B) system in anhydrous organic media suggested that in solvent-free conditions a step-growth mechanism operates involving the effective sequential addition of an 'AB' unit. Subsequent optimisation work led to development of an efficient solvent-free process using lipase B from Candida antarctica as catalyst at temperatures of around 60°C, producing polyesters with unique properties compared to their counterparts synthesised using conventional high temperature processes. The present work describes the synthesis and unambiguous characterisation by GPC of a series of key oligomers formed during the enzymatic process, enabling a clearer understanding of the polymer assembly route. Use of semi-quantitative methods to compare the reactivity of these oligomeric species along the proposed enzymatic reaction pathway further clarifies the polymerisation mechanism and explains the differences between the final ... |
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