Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ...
As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 contro...
Main Authors: | , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
PANGAEA
2011
|
Subjects: | |
Online Access: | https://dx.doi.org/10.1594/pangaea.812009 https://doi.pangaea.de/10.1594/PANGAEA.812009 |
id |
ftdatacite:10.1594/pangaea.812009 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.1594/pangaea.812009 2024-09-09T19:35:42+00:00 Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ... Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe 2011 application/zip https://dx.doi.org/10.1594/pangaea.812009 https://doi.pangaea.de/10.1594/PANGAEA.812009 en eng PANGAEA https://dx.doi.org/10.1016/j.ecoenv.2010.08.040 Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 Biological sample International Polar Year 2007-2008 IPY article Collection Supplementary Publication Series of Datasets 2011 ftdatacite https://doi.org/10.1594/pangaea.81200910.1016/j.ecoenv.2010.08.040 2024-08-01T10:57:37Z As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone ... : Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 ... Article in Journal/Newspaper Canis lupus Greenland International Polar Year IPY minke whale DataCite Greenland |
institution |
Open Polar |
collection |
DataCite |
op_collection_id |
ftdatacite |
language |
English |
topic |
Biological sample International Polar Year 2007-2008 IPY |
spellingShingle |
Biological sample International Polar Year 2007-2008 IPY Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ... |
topic_facet |
Biological sample International Polar Year 2007-2008 IPY |
description |
As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone ... : Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 ... |
format |
Article in Journal/Newspaper |
author |
Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe |
author_facet |
Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe |
author_sort |
Kirkegaard, Maja |
title |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ... |
title_short |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ... |
title_full |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ... |
title_fullStr |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ... |
title_full_unstemmed |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber ... |
title_sort |
thyroid hormone and gland status of greenland sledge dogs (canis lupus familiaris) exposed to contaminated blubber ... |
publisher |
PANGAEA |
publishDate |
2011 |
url |
https://dx.doi.org/10.1594/pangaea.812009 https://doi.pangaea.de/10.1594/PANGAEA.812009 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Canis lupus Greenland International Polar Year IPY minke whale |
genre_facet |
Canis lupus Greenland International Polar Year IPY minke whale |
op_relation |
https://dx.doi.org/10.1016/j.ecoenv.2010.08.040 |
op_rights |
Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 |
op_doi |
https://doi.org/10.1594/pangaea.81200910.1016/j.ecoenv.2010.08.040 |
_version_ |
1809905052628811776 |