Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber, supplement to: Kirkegaard, Maja; Sonne, Christian; Dietz, Rune; Letcher, Robert J; Jensen, Asger L; Hansen, Signe Stige; Jenssen, Bjørn Munro; Grandjean, Philippe (2011): Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds. Ecotoxicology and Environmental Safety, 74(1), 157-163

As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 contro...

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Bibliographic Details
Main Authors: Kirkegaard, Maja, Sonne, Christian, Dietz, Rune, Letcher, Robert J, Jensen, Asger L, Hansen, Signe Stige, Jenssen, Bjørn Munro, Grandjean, Philippe
Format: Article in Journal/Newspaper
Language:English
Published: PANGAEA - Data Publisher for Earth & Environmental Science 2011
Subjects:
Biological sample
International Polar Year 2007-2008 IPY
Bjørn
Dietz
Greenland
Stige
Canis lupus
International Polar Year
IPY
minke whale
Online Access:https://dx.doi.org/10.1594/pangaea.812009
https://doi.pangaea.de/10.1594/PANGAEA.812009
Description
Summary:As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics. : Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150

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