In vivo Nord 1: Chlorpyrifos-methyl
Aim: To investigate whether Atlantic cod that feed close to aquatic breeding facilities are affected by chlorpyrifos-methyl. Feeding experiment with chlorpyrifos-methyl, an organophosphorous pesticide detected in plant based salmon feed. Based on previous experiments using salmon. Doses: 0, 0.5, 5.0...
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| Format: | Article in Journal/Newspaper |
| Language: | unknown |
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FAIRDOMHub
2019
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| Online Access: | https://dx.doi.org/10.15490/fairdomhub.1.study.593.1 https://fairdomhub.org/studies/593/snapshots/1 |
| Summary: | Aim: To investigate whether Atlantic cod that feed close to aquatic breeding facilities are affected by chlorpyrifos-methyl. Feeding experiment with chlorpyrifos-methyl, an organophosphorous pesticide detected in plant based salmon feed. Based on previous experiments using salmon. Doses: 0, 0.5, 5.0, 25 mg/kg) chlorpyrifos-methyl. Duration: 30 days Set-up: Three tanks per treatment (12 in total) Samples include: Liver, plasma, bile, brain. Analysis include: - Have RNAseq and metabolomics from 36 liver samples - Plasma cholinesterase, cortisol, ASAT, ALAT, and total protein (how many?) - EROD on liver samples (how many?) - Chemical levels of chlorpyrifos-methyl and main metabolite TCP in liver and bile (how many?) - Hypoxia stress test (how many?) |
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