Enzymatic synthesis of ester prodrugs of acyclic nucleoside analogues by Candida antarctica lipase

New enzymatic method of transesterification of DHPA, acyclovir and ganciclovir using various vinyl esters differing in lenghts of aliphatic chains catalyzed by immobilized Candida antarctica lipase was worked out.

Bibliographic Details
Main Authors: Lamatová, N. (Nikola), Krečmerová, M. (Marcela), Spiwok, V., Brabcová, J. (Jana)
Format: Other/Unknown Material
Language:English
Published: 2015
Subjects:
vinil esters
lipase
enzymatic esterification
Antarc*
Antarctica
Online Access:http://hdl.handle.net/11104/0256245
Description
Summary:New enzymatic method of transesterification of DHPA, acyclovir and ganciclovir using various vinyl esters differing in lenghts of aliphatic chains catalyzed by immobilized Candida antarctica lipase was worked out.

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