First Cinchona-catalyzed synthesis of 1,4-dihydropyridine analogs

• Main Authors: Heiran, Roghayeh, Mohammadi, Somayeh, Herrera, Raquel P., Marqués-López, Eugenia
• Format: Still Image
• Language: unknown
• Published: 2013
• Subjects: Orca
• Online Access: http://hdl.handle.net/10261/112571

Trabajo presentado al 5th OrganoCatalysis Cost Action (ORCA) Meeting and Training School celebrado en Alicante (España) del 17 al 19 de octubre de 2013. 1,4-Dihydropyridine derivatives (1,4-DHPs) are an important class of heterocyclic compounds because of their interesting biological properties, such as vasodilators, antihypertensive, antiinflammatory, antihypoxic and anti-ischemic agents, as well as calcium channel modulators of the nifedipine type. The interest and biological importante of 1.4-dihydropyridine anaiogs encouraged us to design and develop a new straightiorward route for their asymmetric preparation by enantioselective organocatalysis. In this study, we report our promising results concerning the first asymmetric synthesis of highly functionalized dihydropyridines 3 via reaction of enamines 1 with malononitriies 2 in presence of chirai organocatalysts. Peer Reviewed