| Summary: | Trabajo presentado al 5th OrganoCatalysis Cost Action (ORCA) Meeting and Training School celebrado en Alicante (España) del 17 al 19 de octubre de 2013. 1,4-Dihydropyridine derivatives (1,4-DHPs) are an important class of heterocyclic compounds because of their interesting biological properties, such as vasodilators, antihypertensive, antiinflammatory, antihypoxic and anti-ischemic agents, as well as calcium channel modulators of the nifedipine type. The interest and biological importante of 1.4-dihydropyridine anaiogs encouraged us to design and develop a new straightiorward route for their asymmetric preparation by enantioselective organocatalysis. In this study, we report our promising results concerning the first asymmetric synthesis of highly functionalized dihydropyridines 3 via reaction of enamines 1 with malononitriies 2 in presence of chirai organocatalysts. Peer Reviewed
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