Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances

BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse. OBJECTIVE: We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)...

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Bibliographic Details
Published in:Environmental Health Perspectives
Main Authors: Høyer, Birgit Bjerre, Ramlau-Hansen, Cecilia Høst, Vrijheid, Martine, Valvi, Damaskini, Pedersen, Henning Sloth, Zviezdai, Valentyna, Jönsson, Bo A G, Lindh, Christian H, Bonde, Jens Peter, Toft, Gunnar
Format: Article in Journal/Newspaper
Language:English
Published: 2015
Subjects:
Alkanesulfonic Acids
Anthropometry
Caprylates
Child
Preschool
Environmental Exposure
Environmental Pollutants
Female
Fluorocarbons
Greenland
Humans
Male
Pregnancy
Prenatal Exposure Delayed Effects
Ukraine
greenlandic
Online Access:https://curis.ku.dk/portal/da/publications/anthropometry-in-5-to-9yearold-greenlandic-and-ukrainian-children-in-relation-to-prenatal-exposure-to-perfluorinated-alkyl-substances(fb075701-97f8-4daf-8145-35bca16ecfba).html
https://doi.org/10.1289/ehp.1408881
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Summary:BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse. OBJECTIVE: We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 SD) and waist-to-height ratio (WHtR) > 0.5 at 5-9 years of age. METHODS: Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analyzed for PFOA and PFOS using liquid chromatography-tandem mass spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorized (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalized linear models. RESULTS: Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 [95% confidence interval (CI): 0.82, 1.53] in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For 1-ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis. CONCLUSIONS: The results indicate that prenatal PFOA and PFOS exposures may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposures were not associated with overweight.

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