Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of envi...

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Bibliographic Details
Published in:Reproductive Toxicology
Main Authors: Toft, Gunnar, Lenters, Virissa, Vermeulen, Roel, Heederik, Dick, Thomsen, Cathrine, Becher, Georg, Giwercman, Aleksander, Bizzaro, Davide, Manicardi, Gian Carlo, Spanò, Marcello, Rylander, Lars, Pedersen, Henning S, Struciński, Paweł, Zviezdai, Valentyna, Bonde, Jens Peter
Format: Article in Journal/Newspaper
Language:English
Published: 2014
Subjects:
Adult
DNA Damage
Environmental Monitoring
Environmental Pollutants
Estradiol
Flame Retardants
Follicle Stimulating Hormone
Greenland
Halogenated Diphenyl Ethers
Humans
In Situ Nick-End Labeling
Luteinizing Hormone
Male
Poland
Polybrominated Biphenyls
Sperm Count
Sperm Motility
Testosterone
Ukraine
Young Adult
Arctic
Online Access:https://curis.ku.dk/portal/da/publications/exposure-to-polybrominated-diphenyl-ethers-and-male-reproductive-function-in-greenland-poland-and-ukraine(89d0c30f-781e-40ae-bc64-9aceaf67d24e).html
https://doi.org/10.1016/j.reprotox.2013.10.002
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Summary:Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

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