Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men
We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in...
Published in: | Reproductive Toxicology |
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2015
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Online Access: | https://curis.ku.dk/portal/da/publications/cadmium-may-impair-prostate-function-as-measured-by-prostate-specific-antigen-in-semen(888d66fb-caaf-4627-b82f-92e6a85686cd).html https://doi.org/10.1016/j.reprotox.2015.01.010 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/888d66fb-caaf-4627-b82f-92e6a85686cd 2024-05-19T07:41:09+00:00 Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men Andreucci, Alessandro Mocevic, Emina Jönsson, Bo A G Giwercman, Aleksander Giwercman, Yvonne Lundberg Toft, Gunnar Lundh, Thomas Bizzaro, Davide Specht, Ina Olmer Bonde, Jens Peter 2015-06 https://curis.ku.dk/portal/da/publications/cadmium-may-impair-prostate-function-as-measured-by-prostate-specific-antigen-in-semen(888d66fb-caaf-4627-b82f-92e6a85686cd).html https://doi.org/10.1016/j.reprotox.2015.01.010 eng eng info:eu-repo/semantics/closedAccess Andreucci , A , Mocevic , E , Jönsson , B A G , Giwercman , A , Giwercman , Y L , Toft , G , Lundh , T , Bizzaro , D , Specht , I O & Bonde , J P 2015 , ' Cadmium may impair prostate function as measured by prostate specific antigen in semen : A cross-sectional study among European and Inuit men ' , Reproductive Toxicology , vol. 53 , pp. 33-8 . https://doi.org/10.1016/j.reprotox.2015.01.010 Adolescent Adult Cadmium Cross-Sectional Studies Greenland Humans Inuits Male Middle Aged Poland Polymorphism Genetic Prostate Prostate-Specific Antigen Receptors Androgen Semen Ukraine Young Adult Zinc article 2015 ftcopenhagenunip https://doi.org/10.1016/j.reprotox.2015.01.010 2024-04-25T00:45:02Z We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action. Article in Journal/Newspaper Greenland greenlandic inuit inuits University of Copenhagen: Research Reproductive Toxicology 53 33 38 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Adolescent Adult Cadmium Cross-Sectional Studies Greenland Humans Inuits Male Middle Aged Poland Polymorphism Genetic Prostate Prostate-Specific Antigen Receptors Androgen Semen Ukraine Young Adult Zinc |
spellingShingle |
Adolescent Adult Cadmium Cross-Sectional Studies Greenland Humans Inuits Male Middle Aged Poland Polymorphism Genetic Prostate Prostate-Specific Antigen Receptors Androgen Semen Ukraine Young Adult Zinc Andreucci, Alessandro Mocevic, Emina Jönsson, Bo A G Giwercman, Aleksander Giwercman, Yvonne Lundberg Toft, Gunnar Lundh, Thomas Bizzaro, Davide Specht, Ina Olmer Bonde, Jens Peter Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men |
topic_facet |
Adolescent Adult Cadmium Cross-Sectional Studies Greenland Humans Inuits Male Middle Aged Poland Polymorphism Genetic Prostate Prostate-Specific Antigen Receptors Androgen Semen Ukraine Young Adult Zinc |
description |
We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action. |
format |
Article in Journal/Newspaper |
author |
Andreucci, Alessandro Mocevic, Emina Jönsson, Bo A G Giwercman, Aleksander Giwercman, Yvonne Lundberg Toft, Gunnar Lundh, Thomas Bizzaro, Davide Specht, Ina Olmer Bonde, Jens Peter |
author_facet |
Andreucci, Alessandro Mocevic, Emina Jönsson, Bo A G Giwercman, Aleksander Giwercman, Yvonne Lundberg Toft, Gunnar Lundh, Thomas Bizzaro, Davide Specht, Ina Olmer Bonde, Jens Peter |
author_sort |
Andreucci, Alessandro |
title |
Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men |
title_short |
Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men |
title_full |
Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men |
title_fullStr |
Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men |
title_full_unstemmed |
Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men |
title_sort |
cadmium may impair prostate function as measured by prostate specific antigen in semen:a cross-sectional study among european and inuit men |
publishDate |
2015 |
url |
https://curis.ku.dk/portal/da/publications/cadmium-may-impair-prostate-function-as-measured-by-prostate-specific-antigen-in-semen(888d66fb-caaf-4627-b82f-92e6a85686cd).html https://doi.org/10.1016/j.reprotox.2015.01.010 |
genre |
Greenland greenlandic inuit inuits |
genre_facet |
Greenland greenlandic inuit inuits |
op_source |
Andreucci , A , Mocevic , E , Jönsson , B A G , Giwercman , A , Giwercman , Y L , Toft , G , Lundh , T , Bizzaro , D , Specht , I O & Bonde , J P 2015 , ' Cadmium may impair prostate function as measured by prostate specific antigen in semen : A cross-sectional study among European and Inuit men ' , Reproductive Toxicology , vol. 53 , pp. 33-8 . https://doi.org/10.1016/j.reprotox.2015.01.010 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.reprotox.2015.01.010 |
container_title |
Reproductive Toxicology |
container_volume |
53 |
container_start_page |
33 |
op_container_end_page |
38 |
_version_ |
1799480742230622208 |