Cadmium may impair prostate function as measured by prostate specific antigen in semen:A cross-sectional study among European and Inuit men

We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in...

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Bibliographic Details
Published in:Reproductive Toxicology
Main Authors: Andreucci, Alessandro, Mocevic, Emina, Jönsson, Bo A G, Giwercman, Aleksander, Giwercman, Yvonne Lundberg, Toft, Gunnar, Lundh, Thomas, Bizzaro, Davide, Specht, Ina Olmer, Bonde, Jens Peter
Format: Article in Journal/Newspaper
Language:English
Published: 2015
Subjects:
Adolescent
Adult
Cadmium
Cross-Sectional Studies
Greenland
Humans
Inuits
Male
Middle Aged
Poland
Polymorphism
Genetic
Prostate
Prostate-Specific Antigen
Receptors
Androgen
Semen
Ukraine
Young Adult
Zinc
greenlandic
inuit
inuits
Online Access:https://curis.ku.dk/portal/da/publications/cadmium-may-impair-prostate-function-as-measured-by-prostate-specific-antigen-in-semen(888d66fb-caaf-4627-b82f-92e6a85686cd).html
https://doi.org/10.1016/j.reprotox.2015.01.010
Description
Summary:We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.

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