A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33
OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to id...
Published in: | Neurology |
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Language: | English |
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2009
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Online Access: | https://curis.ku.dk/portal/da/publications/a-novel-stroke-locus-identified-in-a-northern-sweden-pedigree(850db030-2202-11df-8ed1-000ea68e967b).html https://doi.org/10.1212/WNL.0b013e3181c34b1d |
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ftcopenhagenunip:oai:pure.atira.dk:publications/850db030-2202-11df-8ed1-000ea68e967b 2023-05-15T17:44:20+02:00 A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 Janunger, T. Nilsson-Ardnor, S. Wiklund, P.-G. Lindgren, P. Escher, S.A. Lackovic, K. Nilsson, A.K. Stegmayr, B. Asplund, K. Holmberg, Dan Ingemar 2009 https://curis.ku.dk/portal/da/publications/a-novel-stroke-locus-identified-in-a-northern-sweden-pedigree(850db030-2202-11df-8ed1-000ea68e967b).html https://doi.org/10.1212/WNL.0b013e3181c34b1d eng eng info:eu-repo/semantics/restrictedAccess Janunger , T , Nilsson-Ardnor , S , Wiklund , P-G , Lindgren , P , Escher , S A , Lackovic , K , Nilsson , A K , Stegmayr , B , Asplund , K & Holmberg , D I 2009 , ' A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33 ' , Neurology , vol. 73 , no. 21 , pp. 1767-1773 . https://doi.org/10.1212/WNL.0b013e3181c34b1d article 2009 ftcopenhagenunip https://doi.org/10.1212/WNL.0b013e3181c34b1d 2022-02-24T00:03:45Z OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage. Article in Journal/Newspaper Northern Sweden University of Copenhagen: Research Neurology 73 21 1767 1773 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage. |
format |
Article in Journal/Newspaper |
author |
Janunger, T. Nilsson-Ardnor, S. Wiklund, P.-G. Lindgren, P. Escher, S.A. Lackovic, K. Nilsson, A.K. Stegmayr, B. Asplund, K. Holmberg, Dan Ingemar |
spellingShingle |
Janunger, T. Nilsson-Ardnor, S. Wiklund, P.-G. Lindgren, P. Escher, S.A. Lackovic, K. Nilsson, A.K. Stegmayr, B. Asplund, K. Holmberg, Dan Ingemar A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 |
author_facet |
Janunger, T. Nilsson-Ardnor, S. Wiklund, P.-G. Lindgren, P. Escher, S.A. Lackovic, K. Nilsson, A.K. Stegmayr, B. Asplund, K. Holmberg, Dan Ingemar |
author_sort |
Janunger, T. |
title |
A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 |
title_short |
A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 |
title_full |
A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 |
title_fullStr |
A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 |
title_full_unstemmed |
A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 |
title_sort |
novel stroke locus identified in a northern sweden pedigree:linkage to chromosome 9q31-33 |
publishDate |
2009 |
url |
https://curis.ku.dk/portal/da/publications/a-novel-stroke-locus-identified-in-a-northern-sweden-pedigree(850db030-2202-11df-8ed1-000ea68e967b).html https://doi.org/10.1212/WNL.0b013e3181c34b1d |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Janunger , T , Nilsson-Ardnor , S , Wiklund , P-G , Lindgren , P , Escher , S A , Lackovic , K , Nilsson , A K , Stegmayr , B , Asplund , K & Holmberg , D I 2009 , ' A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33 ' , Neurology , vol. 73 , no. 21 , pp. 1767-1773 . https://doi.org/10.1212/WNL.0b013e3181c34b1d |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1212/WNL.0b013e3181c34b1d |
container_title |
Neurology |
container_volume |
73 |
container_issue |
21 |
container_start_page |
1767 |
op_container_end_page |
1773 |
_version_ |
1766146546133368832 |