A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33

OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to id...

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Published in:Neurology
Main Authors: Janunger, T., Nilsson-Ardnor, S., Wiklund, P.-G., Lindgren, P., Escher, S.A., Lackovic, K., Nilsson, A.K., Stegmayr, B., Asplund, K., Holmberg, Dan Ingemar
Format: Article in Journal/Newspaper
Language:English
Published: 2009
Subjects:
Online Access:https://curis.ku.dk/portal/da/publications/a-novel-stroke-locus-identified-in-a-northern-sweden-pedigree(850db030-2202-11df-8ed1-000ea68e967b).html
https://doi.org/10.1212/WNL.0b013e3181c34b1d
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spelling ftcopenhagenunip:oai:pure.atira.dk:publications/850db030-2202-11df-8ed1-000ea68e967b 2023-05-15T17:44:20+02:00 A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33 Janunger, T. Nilsson-Ardnor, S. Wiklund, P.-G. Lindgren, P. Escher, S.A. Lackovic, K. Nilsson, A.K. Stegmayr, B. Asplund, K. Holmberg, Dan Ingemar 2009 https://curis.ku.dk/portal/da/publications/a-novel-stroke-locus-identified-in-a-northern-sweden-pedigree(850db030-2202-11df-8ed1-000ea68e967b).html https://doi.org/10.1212/WNL.0b013e3181c34b1d eng eng info:eu-repo/semantics/restrictedAccess Janunger , T , Nilsson-Ardnor , S , Wiklund , P-G , Lindgren , P , Escher , S A , Lackovic , K , Nilsson , A K , Stegmayr , B , Asplund , K & Holmberg , D I 2009 , ' A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33 ' , Neurology , vol. 73 , no. 21 , pp. 1767-1773 . https://doi.org/10.1212/WNL.0b013e3181c34b1d article 2009 ftcopenhagenunip https://doi.org/10.1212/WNL.0b013e3181c34b1d 2022-02-24T00:03:45Z OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage. Article in Journal/Newspaper Northern Sweden University of Copenhagen: Research Neurology 73 21 1767 1773
institution Open Polar
collection University of Copenhagen: Research
op_collection_id ftcopenhagenunip
language English
description OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.
format Article in Journal/Newspaper
author Janunger, T.
Nilsson-Ardnor, S.
Wiklund, P.-G.
Lindgren, P.
Escher, S.A.
Lackovic, K.
Nilsson, A.K.
Stegmayr, B.
Asplund, K.
Holmberg, Dan Ingemar
spellingShingle Janunger, T.
Nilsson-Ardnor, S.
Wiklund, P.-G.
Lindgren, P.
Escher, S.A.
Lackovic, K.
Nilsson, A.K.
Stegmayr, B.
Asplund, K.
Holmberg, Dan Ingemar
A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33
author_facet Janunger, T.
Nilsson-Ardnor, S.
Wiklund, P.-G.
Lindgren, P.
Escher, S.A.
Lackovic, K.
Nilsson, A.K.
Stegmayr, B.
Asplund, K.
Holmberg, Dan Ingemar
author_sort Janunger, T.
title A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33
title_short A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33
title_full A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33
title_fullStr A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33
title_full_unstemmed A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33
title_sort novel stroke locus identified in a northern sweden pedigree:linkage to chromosome 9q31-33
publishDate 2009
url https://curis.ku.dk/portal/da/publications/a-novel-stroke-locus-identified-in-a-northern-sweden-pedigree(850db030-2202-11df-8ed1-000ea68e967b).html
https://doi.org/10.1212/WNL.0b013e3181c34b1d
genre Northern Sweden
genre_facet Northern Sweden
op_source Janunger , T , Nilsson-Ardnor , S , Wiklund , P-G , Lindgren , P , Escher , S A , Lackovic , K , Nilsson , A K , Stegmayr , B , Asplund , K & Holmberg , D I 2009 , ' A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33 ' , Neurology , vol. 73 , no. 21 , pp. 1767-1773 . https://doi.org/10.1212/WNL.0b013e3181c34b1d
op_rights info:eu-repo/semantics/restrictedAccess
op_doi https://doi.org/10.1212/WNL.0b013e3181c34b1d
container_title Neurology
container_volume 73
container_issue 21
container_start_page 1767
op_container_end_page 1773
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