A novel stroke locus identified in a northern Sweden pedigree:linkage to chromosome 9q31-33

OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to id...

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Bibliographic Details
Published in:Neurology
Main Authors: Janunger, T., Nilsson-Ardnor, S., Wiklund, P.-G., Lindgren, P., Escher, S.A., Lackovic, K., Nilsson, A.K., Stegmayr, B., Asplund, K., Holmberg, Dan Ingemar
Format: Article in Journal/Newspaper
Language:English
Published: 2009
Subjects:
Northern Sweden
Online Access:https://curis.ku.dk/portal/da/publications/a-novel-stroke-locus-identified-in-a-northern-sweden-pedigree(850db030-2202-11df-8ed1-000ea68e967b).html
https://doi.org/10.1212/WNL.0b013e3181c34b1d
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Summary:OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.

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