Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study
OBJECTIVES: Abdominal fat has been identified as a risk marker of cardiometabolic disease independent of overall adiposity. However, it is not clear whether there are ethnic disparities in this risk. We investigated the associations of visceral adipose tissue (VAT) and abdominal subcutaneous adipose...
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2020
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Online Access: | https://curis.ku.dk/portal/da/publications/abdominal-visceral-and-subcutaneous-adipose-tissue-and-associations-with-cardiometabolic-risk-in-inuit-africans-and-europeans(4103a11e-f5a7-4867-bf9a-2ec319b4f6dc).html https://doi.org/10.1136/bmjopen-2020-038071 https://curis.ku.dk/ws/files/248758415/Abdominal_visceral_and_subcutaneous_adipose_tissue_and_associations_with_cardiometabolic_risk_in_Inuit_Africans_and_Europeans.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/4103a11e-f5a7-4867-bf9a-2ec319b4f6dc 2024-04-14T08:12:27+00:00 Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study Rønn, Pernille Falberg Andersen, Gregers Stig Lauritzen, Torsten Christensen, Dirk Lund Aadahl, Mette Carstensen, Bendix Grarup, Niels Jørgensen, Marit Eika 2020-09-14 application/pdf https://curis.ku.dk/portal/da/publications/abdominal-visceral-and-subcutaneous-adipose-tissue-and-associations-with-cardiometabolic-risk-in-inuit-africans-and-europeans(4103a11e-f5a7-4867-bf9a-2ec319b4f6dc).html https://doi.org/10.1136/bmjopen-2020-038071 https://curis.ku.dk/ws/files/248758415/Abdominal_visceral_and_subcutaneous_adipose_tissue_and_associations_with_cardiometabolic_risk_in_Inuit_Africans_and_Europeans.pdf eng eng info:eu-repo/semantics/openAccess Rønn , P F , Andersen , G S , Lauritzen , T , Christensen , D L , Aadahl , M , Carstensen , B , Grarup , N & Jørgensen , M E 2020 , ' Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans : a cross-sectional study ' , BMJ Open , vol. 10 , no. 9 , e038071 . https://doi.org/10.1136/bmjopen-2020-038071 article 2020 ftcopenhagenunip https://doi.org/10.1136/bmjopen-2020-038071 2024-03-21T17:28:10Z OBJECTIVES: Abdominal fat has been identified as a risk marker of cardiometabolic disease independent of overall adiposity. However, it is not clear whether there are ethnic disparities in this risk. We investigated the associations of visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) with cardiometabolic risk factors in three ethnic diverse populations of Inuit, Africans and Europeans. DESIGN: Cross-sectional pooled study. SETTING: Greenland, Kenya and Denmark. METHODS: A total of 5113 participants (2933 Inuit, 1397 Africans and 783 Europeans) from three studies in Greenland, Kenya and Denmark were included. Measurements included abdominal fat distribution assessed by ultrasound, oral glucose tolerance test, hepatic insulin resistance, blood pressure and lipids. The associations were analysed using multiple linear regressions. RESULTS: Across ethnic group and gender, an increase in VAT of 1 SD was associated with higher levels of hepatic insulin resistance (ranging from 14% to 28%), triglycerides (8% to 16%) and lower high-density lipoprotein cholesterol (HDL-C, -1.0 to -0.05 mmol/L) independent of body mass index. VAT showed positive associations with most of the other cardiometabolic risk factors in Inuit and Europeans, but not in Africans. In contrast, SAT was mainly associated with the outcomes in Inuit and Africans. Of notice was that higher SAT was associated with higher HDL-C in African men (0.11 mmol/L, 95% CI: 0.03 to 0.18) and with lower HDL-C in Inuit (-0.07 mmol/L, 95% CI: -0.12 to -0.02), but not in European men (-0.02 mmol/L, 95% CI: -0.09 to 0.05). Generally weaker associations were observed for women. Furthermore, the absolute levels of several of the cardiometabolic outcomes differed between the ethnic groups. CONCLUSIONS: VAT and SAT were associated with several of the cardiometabolic risk factors beyond overall adiposity. Some of these associations were specific to ethnicity, suggesting that ethnicity plays a role in the pathway from abdominal fat to selected ... Article in Journal/Newspaper Greenland inuit University of Copenhagen: Research Greenland BMJ Open 10 9 e038071 |
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Open Polar |
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University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
OBJECTIVES: Abdominal fat has been identified as a risk marker of cardiometabolic disease independent of overall adiposity. However, it is not clear whether there are ethnic disparities in this risk. We investigated the associations of visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) with cardiometabolic risk factors in three ethnic diverse populations of Inuit, Africans and Europeans. DESIGN: Cross-sectional pooled study. SETTING: Greenland, Kenya and Denmark. METHODS: A total of 5113 participants (2933 Inuit, 1397 Africans and 783 Europeans) from three studies in Greenland, Kenya and Denmark were included. Measurements included abdominal fat distribution assessed by ultrasound, oral glucose tolerance test, hepatic insulin resistance, blood pressure and lipids. The associations were analysed using multiple linear regressions. RESULTS: Across ethnic group and gender, an increase in VAT of 1 SD was associated with higher levels of hepatic insulin resistance (ranging from 14% to 28%), triglycerides (8% to 16%) and lower high-density lipoprotein cholesterol (HDL-C, -1.0 to -0.05 mmol/L) independent of body mass index. VAT showed positive associations with most of the other cardiometabolic risk factors in Inuit and Europeans, but not in Africans. In contrast, SAT was mainly associated with the outcomes in Inuit and Africans. Of notice was that higher SAT was associated with higher HDL-C in African men (0.11 mmol/L, 95% CI: 0.03 to 0.18) and with lower HDL-C in Inuit (-0.07 mmol/L, 95% CI: -0.12 to -0.02), but not in European men (-0.02 mmol/L, 95% CI: -0.09 to 0.05). Generally weaker associations were observed for women. Furthermore, the absolute levels of several of the cardiometabolic outcomes differed between the ethnic groups. CONCLUSIONS: VAT and SAT were associated with several of the cardiometabolic risk factors beyond overall adiposity. Some of these associations were specific to ethnicity, suggesting that ethnicity plays a role in the pathway from abdominal fat to selected ... |
format |
Article in Journal/Newspaper |
author |
Rønn, Pernille Falberg Andersen, Gregers Stig Lauritzen, Torsten Christensen, Dirk Lund Aadahl, Mette Carstensen, Bendix Grarup, Niels Jørgensen, Marit Eika |
spellingShingle |
Rønn, Pernille Falberg Andersen, Gregers Stig Lauritzen, Torsten Christensen, Dirk Lund Aadahl, Mette Carstensen, Bendix Grarup, Niels Jørgensen, Marit Eika Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study |
author_facet |
Rønn, Pernille Falberg Andersen, Gregers Stig Lauritzen, Torsten Christensen, Dirk Lund Aadahl, Mette Carstensen, Bendix Grarup, Niels Jørgensen, Marit Eika |
author_sort |
Rønn, Pernille Falberg |
title |
Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study |
title_short |
Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study |
title_full |
Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study |
title_fullStr |
Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study |
title_full_unstemmed |
Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans:a cross-sectional study |
title_sort |
abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in inuit, africans and europeans:a cross-sectional study |
publishDate |
2020 |
url |
https://curis.ku.dk/portal/da/publications/abdominal-visceral-and-subcutaneous-adipose-tissue-and-associations-with-cardiometabolic-risk-in-inuit-africans-and-europeans(4103a11e-f5a7-4867-bf9a-2ec319b4f6dc).html https://doi.org/10.1136/bmjopen-2020-038071 https://curis.ku.dk/ws/files/248758415/Abdominal_visceral_and_subcutaneous_adipose_tissue_and_associations_with_cardiometabolic_risk_in_Inuit_Africans_and_Europeans.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
Rønn , P F , Andersen , G S , Lauritzen , T , Christensen , D L , Aadahl , M , Carstensen , B , Grarup , N & Jørgensen , M E 2020 , ' Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans : a cross-sectional study ' , BMJ Open , vol. 10 , no. 9 , e038071 . https://doi.org/10.1136/bmjopen-2020-038071 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/bmjopen-2020-038071 |
container_title |
BMJ Open |
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10 |
container_issue |
9 |
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e038071 |
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