Development of a nanoparticle-based oral vaccine for Atlantic salmon against ISAV using an alphavirus replicon as adjuvant

• Published in: Fish & Shellfish Immunology
• Main Authors: Rivas Aravena, Andrea, Fuentes, Jazmin, Cartagena, Julio, Brito, Tania, Poggio, Thelma Veronica, la Torre, Jose Leonardo, Mendoza, Hegaly, Gonzalez Nilo, Fernando Danilo, Sandino, Ana María, Eugenio, Emilio Osvaldo
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier
• Subjects: Nanoparticles; Adjuvant; Vaccine; Atlantic Salmon; Salmon Alphavirus; Isav; https://purl.org/becyt/ford/3.4; https://purl.org/becyt/ford/3; Argentina; Torre; Aravena; Atlantic salmon
• Online Access: http://hdl.handle.net/11336/4151

Adjuvants used in vaccine aquaculture are frequently harmful for the fish, causing melanosis, granulomas and kidney damage. Along with that, vaccines are mostly administered by injection, causing pain and stress to the fish. We used the DNA coding for the replicase of alphavirus as adjuvant (Ad) of...