A rational approach to the regioselective deacetylation of 2′,3′,5′-tri-O-acetyluridine by Novozym 435 catalysed alcoholysis

• Published in: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
• Main Authors: Gudiño, Esteban Dario, Iglesias, Luis Emilio, Ferreira, María Luján
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier Science
• Subjects: Candida antarctica lipase B; Molecular modeling; Nucleoside; Regioselectivity; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1; Argentina; Ferreira; Quilmes; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/11336/243530

To give a rational explanation for the behaviour of 2′,3′,5′-tri-O-acetyluridine (TAU) catalysed alcoholysis using Novozym 435, the commercial biocatalyst with immobilized Candida antarctica lipase B (CALB), a set of experiments analyzing the role of the alcohol/substrate (A/S) molar ratio, alcohol/...