An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Populat...
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Language: | English |
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ftconicet:oai:ri.conicet.gov.ar:11336/138624 2023-10-09T21:52:03+02:00 An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations Kayser, Manfred Krawczak, Michael Excoffier, Laurent Dieltjes, Patrick Corach, Daniel Pascali, Vincente Gehrig, Christian Bernini, Luigi F. Jespersen, J. Bakker, Egbert Roewer, Lutz De Knijff, Peter application/pdf http://hdl.handle.net/11336/138624 eng eng Cell Press info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/ajhg/fulltext/S0002-9297(07)61425-6 info:eu-repo/semantics/altIdentifier/doi/10.1086/319510 http://hdl.handle.net/11336/138624 Kayser, Manfred; Krawczak, Michael; Excoffier, Laurent; Dieltjes, Patrick; Corach, Daniel; et al.; An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations; Cell Press; American Journal Of Human Genetics; 68; 4; 4-2001; 990-1018 0002-9297 CONICET Digital CONICET info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ YSTRS WORLD POPULATIONS HAPLOTYPES https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion ftconicet https://doi.org/10.1086/319510 2023-09-24T18:30:34Z The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86-.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ΦST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure. Fil: Kayser, Manfred. Max Planck Institute for Evolutionary Anthropology; Alemania Fil: Krawczak, Michael. University of Wales Reino Unido Fil: Excoffier, Laurent. Universidad de Genova; España Fil: Dieltjes, Patrick. Leiden University; Países Bajos Fil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina Fil: Pascali, Vincente. Universidad Catolica del Sacre Cuore; Italia Fil: Gehrig, Christian. Institute of Legal Medicine; Italia Fil: Bernini, Luigi F. Leiden ... Article in Journal/Newspaper Greenland inuit CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) Greenland Argentina Genova ENVELOPE(-82.713,-82.713,-79.863,-79.863) Bajos ENVELOPE(-56.317,-56.317,-63.467,-63.467) The American Journal of Human Genetics 68 4 990 1018 |
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Open Polar |
collection |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
op_collection_id |
ftconicet |
language |
English |
topic |
YSTRS WORLD POPULATIONS HAPLOTYPES https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
spellingShingle |
YSTRS WORLD POPULATIONS HAPLOTYPES https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 Kayser, Manfred Krawczak, Michael Excoffier, Laurent Dieltjes, Patrick Corach, Daniel Pascali, Vincente Gehrig, Christian Bernini, Luigi F. Jespersen, J. Bakker, Egbert Roewer, Lutz De Knijff, Peter An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations |
topic_facet |
YSTRS WORLD POPULATIONS HAPLOTYPES https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
description |
The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86-.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ΦST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure. Fil: Kayser, Manfred. Max Planck Institute for Evolutionary Anthropology; Alemania Fil: Krawczak, Michael. University of Wales Reino Unido Fil: Excoffier, Laurent. Universidad de Genova; España Fil: Dieltjes, Patrick. Leiden University; Países Bajos Fil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina Fil: Pascali, Vincente. Universidad Catolica del Sacre Cuore; Italia Fil: Gehrig, Christian. Institute of Legal Medicine; Italia Fil: Bernini, Luigi F. Leiden ... |
format |
Article in Journal/Newspaper |
author |
Kayser, Manfred Krawczak, Michael Excoffier, Laurent Dieltjes, Patrick Corach, Daniel Pascali, Vincente Gehrig, Christian Bernini, Luigi F. Jespersen, J. Bakker, Egbert Roewer, Lutz De Knijff, Peter |
author_facet |
Kayser, Manfred Krawczak, Michael Excoffier, Laurent Dieltjes, Patrick Corach, Daniel Pascali, Vincente Gehrig, Christian Bernini, Luigi F. Jespersen, J. Bakker, Egbert Roewer, Lutz De Knijff, Peter |
author_sort |
Kayser, Manfred |
title |
An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations |
title_short |
An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations |
title_full |
An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations |
title_fullStr |
An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations |
title_full_unstemmed |
An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations |
title_sort |
extensive analysis of y-chromosomal microsatellite haplotypes in globally dispersed human populations |
publisher |
Cell Press |
url |
http://hdl.handle.net/11336/138624 |
long_lat |
ENVELOPE(-82.713,-82.713,-79.863,-79.863) ENVELOPE(-56.317,-56.317,-63.467,-63.467) |
geographic |
Greenland Argentina Genova Bajos |
geographic_facet |
Greenland Argentina Genova Bajos |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_relation |
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/ajhg/fulltext/S0002-9297(07)61425-6 info:eu-repo/semantics/altIdentifier/doi/10.1086/319510 http://hdl.handle.net/11336/138624 Kayser, Manfred; Krawczak, Michael; Excoffier, Laurent; Dieltjes, Patrick; Corach, Daniel; et al.; An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations; Cell Press; American Journal Of Human Genetics; 68; 4; 4-2001; 990-1018 0002-9297 CONICET Digital CONICET |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
op_doi |
https://doi.org/10.1086/319510 |
container_title |
The American Journal of Human Genetics |
container_volume |
68 |
container_issue |
4 |
container_start_page |
990 |
op_container_end_page |
1018 |
_version_ |
1779315192023220224 |