An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations

The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Populat...

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Bibliographic Details
Published in:The American Journal of Human Genetics
Main Authors: Kayser, Manfred, Krawczak, Michael, Excoffier, Laurent, Dieltjes, Patrick, Corach, Daniel, Pascali, Vincente, Gehrig, Christian, Bernini, Luigi F., Jespersen, J., Bakker, Egbert, Roewer, Lutz, De Knijff, Peter
Format: Article in Journal/Newspaper
Language:English
Published: Cell Press
Subjects:
YSTRS
WORLD POPULATIONS
HAPLOTYPES
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Greenland
Argentina
Genova
Bajos
inuit
Online Access:http://hdl.handle.net/11336/138624
Description
Summary:The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86-.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ΦST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure. Fil: Kayser, Manfred. Max Planck Institute for Evolutionary Anthropology; Alemania Fil: Krawczak, Michael. University of Wales Reino Unido Fil: Excoffier, Laurent. Universidad de Genova; España Fil: Dieltjes, Patrick. Leiden University; Países Bajos Fil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina Fil: Pascali, Vincente. Universidad Catolica del Sacre Cuore; Italia Fil: Gehrig, Christian. Institute of Legal Medicine; Italia Fil: Bernini, Luigi F. Leiden ...

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