nance of polyploid cell growth in breast cancer cells. Of 5760 human genes screened, 177 were found to induce severe DNA content alterations on prolonged transient silencing. Association with response to DNA damage stim-ulus and DNA repair was found to be the most enriche ional validation analysis o...
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| Format: | Text |
| Language: | English |
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.688.252 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981730/pdf/neo1211_0877.pdf |
| Summary: | nance of polyploid cell growth in breast cancer cells. Of 5760 human genes screened, 177 were found to induce severe DNA content alterations on prolonged transient silencing. Association with response to DNA damage stim-ulus and DNA repair was found to be the most enriche ional validation analysis of these genes highlighted GINS2 a ccu-mulation of endogenous DNA damage, and impairing and induction of polyploidy by suppression of GINS2 was atic analysis of published gene expression and DNA copy NS2 to be associated with the aggressive characteristics o lear GINS2 protein levels distinguished actively proliferating g as tial t Abbreviati qRT- ll spot microarray |
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