Clinical Medicine Insights: Reproductive Health Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years anna Merilainen1, sini peuhkurinen1, timppa honkasalo1, paivi laitinen2, hannaleena Kokkonen1
OBJECTIVE: To evaluate the efficacy of first trimester combined screening for Down’s syndrome in Northern Finland during the first 10 years of practice. cutoff was 1:250. The study period was divided into two time periods; 2002–2006 and 2007–2011. RESULTS: During the first half of the study period,...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Text |
| Language: | English |
| Subjects: | |
| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.673.7128 http://www.la-press.com/redirect_file.php?fileId%3D5764%26fileType%3Dpdf%26filename%3D4313-CMRH-Combined-First-Trimester-Screening-in-Northern-Finland%3A-Experiences-of.pdf |
| Summary: | OBJECTIVE: To evaluate the efficacy of first trimester combined screening for Down’s syndrome in Northern Finland during the first 10 years of practice. cutoff was 1:250. The study period was divided into two time periods; 2002–2006 and 2007–2011. RESULTS: During the first half of the study period, the detection rate (DR) was 77.3 % with a 4.9 % false-positive rate (FPR). During the latter half, the DR was 77.1 % with a 2.8 % FPR. CONCLUSIONS: An important issue is the number of invasive procedures needed to detect one case of Down’s syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9 % to 2.8 % and the number of invasive procedures needed to detect one case of Down’s syndrome lowered from 15 to 11. KEY WORDS: Down’s syndrome, first trimester, nuchal translucency, combined screening, singleton pregnancy |
|---|