EDITORIAL CONFERENCE REPORTS: 4th Intl Workshop on Clinical Pharmacology of HIV Therapy
• Can low NVP plasma concentrations explain the results seen in the EFV and NVP containing arms of the NARVAL study? • Up to one third of patients receiving standard doses of NNRTIs may be being underdosed • Nelfinavir concentrations are significantly higher in HIV/ HCV co-infected patients with cir...
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| Format: | Text |
| Language: | English |
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2003
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.657.8412 http://hiv-druginteractions.org/data/NewsItem/8_HTB.Vol4No4.PK_articles.pdf |
| Summary: | • Can low NVP plasma concentrations explain the results seen in the EFV and NVP containing arms of the NARVAL study? • Up to one third of patients receiving standard doses of NNRTIs may be being underdosed • Nelfinavir concentrations are significantly higher in HIV/ HCV co-infected patients with cirrhosis • Less diarrhoea and bioequivalence with the new nelfinavir 625mg tablet • The potential for probenecid to have a serious interaction with HIV-1 protease inhibitors • PK studies reveal significant sex/gender differences • Pregnancy-related studies • New test to measure intracellular levels of nucleosides • Case studies for therapeutic drug monitoring (TDM) • Launch of guide to use of drug level monitoring 10th Conference on Retroviruses and OIs (CROI) 10 • Pharmacokinetics papers presented at CROI • Paediatric studies from CROI ANTIRETROVIRALS 19 • T-20 Access programme to continue in UK for a further two months • Durability and success capability of HAART: 4.5 years follow-up • Older HIV-positive patients in the era of HAART: changing of a scenario • Immune reconstitution in older HIV-positive individuals TREATMENT ACCESS 22 • The City turns up the heat on drug companies to make treatment available in poorest countries • Lancet commentary concludes that prevention and treatment in South Africa are affordable and desirable HIV treatment bulletin • South Africa treatment protests go global • Gilead to sell tenofovir at cost to 68 countries • New advocacy coalition demands emergency funding from rich governments for Global Fund METABOLIC COMPLICATIONS 25 • Statins and fibrates both relatively effective for PI-induced hyperlipidemia • Pioglitazone subjectively improves body shape abnormalities |
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